3925 N Duke Street #121Durham, NC 27704

Prime Durham Location: Spacious 2400 sq ft Office/ Medical Space at 3925 N Duke St, Ste. 121!'' Description Office/ Medical Space for Lease | 3925 N Duke St, Suite 121 | Durham, NC 27704 Available in March, this versatile 2400 sq ft. Office/ Medical suite offers an exceptional opportunity in one of Durham's most convenient and visible locations--just minutes from downtown and Duke Regional Hospital. Previously home to a dental practice and most recently a salon, this well-configured space is designed for flexibility and ready to support a wide range of professional and service-based businesses. The layout features five private offices thoughtfully arranged around an open main workspace, creating an efficient flow for clients and staff alike. A spacious reception area provides a welcoming first impression, while a separate staff/filing room adds valuable back-of-house functionality. The suite includes one bathroom and is finished throughout with modern, low-maintenance LVP flooring. Highlights include: Five private offices plus open central workspace Large reception area ideal for client-facing businesses Dedicated staff/filing room Contemporary LVP flooring throughout Previously configured for dental and salon use Prime location near Duke Regional Hospital and downtown Durham This space is well-suited for medical or dental practices, beauty and wellness studios, professional offices, or other service-oriented businesses seeking a central, accessible Durham location with built-in flexibility and strong potential.

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Last Updated

Feb 18, 2026

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